Kiadis Pharma announces continued collaboration with Professor Velardi on its lead product ATIR™
Oncology focused biopharmaceutical company Kiadis Pharma announces today that Andrea Velardi, M.D., Professor of Clinical Immunology at the University of Perugia, Italy and Kiadis Pharma are continuing their collaboration on ATIR™, a product in clinical development for enabling the use of a mismatched donor in a bone marrow transplantation by preventing acute Graft versus Host Disease (GvHD) for end stage leukemia patients. Under the agreement Professor Velardi will continue the development on the selective depletion of allo-reactive T cells from mismatched donors using Kiadis Pharma’s ATIR™. Kiadis Pharma is preparing for a multi-center pivotal study on ATIR™ to start early 2009 and Professor Velardi will participate in this upcoming study.
“We are very pleased with our continued collaboration with the University of Perugia and Professor Velardi, who is a leader in the field of mismatched bone marrow transplantations,” says Dr. Manja Bouman, CEO of Kiadis Pharma. “This collaboration is an important milestone in the development of ATIR™ as a revolutionary approach to provide safe and potentially life-saving mismatched bone marrow transplantations as a treatment option for end-stage leukemia patients.”
Professor Andrea Velardi says: “So far, we have treated 25 blood cancer patients who have received bone marrow from mismatched donors, including donor immune cells that are selectively depleted of cells causing acute Graft versus Host Disease using the ATIR™ process. The results so far are promising and I am therefore very pleased to continue to work with Kiadis Pharma in this field.”
About ATIR™
ATIR™ is designed to prevent life-threatening acute GvHD by eliminating the immune cells from the donor graft that otherwise attack the patient’s body. Useful donor immune cells that can fight infections and remaining tumor cells are, however, spared, allowing rapid and safe donor immune reconstitution post transplantation. Acute GvHD is one of the complications of allogeneic bone marrow transplantations. By preventing acute GvHD, ATIR™ enables the use of a mismatched (haplo identical) donor thereby addressing a significant limitation in bone marrow transplantations, which is the timely availability of a donor. By allowing the re-infusion of relatively large numbers of treated donor T-cells in the patient safely, without causing life threatening acute GvHD, ATIR™ can help fight infections early on and improve the successful outcome of a transplantation.
More news
- Kiadis Pharma receives IND approval from FDA to start pivotal clinical trial with ATIR™ 8-7-2010
- Kiadis Pharma Provides ATIR™ Update: Two Year Follow-Up Data Show No Cases of Transplant Related Mortality - FDA grants ATIR™ Orphan Drug Status as a Medicinal Cell Based Therapy to Reduce Transplant Related Mortality 28-4-2010
- Kiadis Pharma announces enrollment of first patients in a multinational registration study for ATIR™ 29-11-2009
- Promising clinical data from Kiadis Pharma’s lead product ATIR™ will be presented at the 51st American Society of Hematology’s (ASH) Annual Meeting 5-11-2009
- Kiadis Pharma reports ATIR™ clinical data, further supporting its potential in mismatched bone marrow transplantations - ATIR™ data presented at the annual EBMT Presidential Symposium 8-4-2009
- Kiadis Pharma presents at the EBMT in Göteborg 31-3-2009
- Kiadis Pharma’s lead investigator presents results ATIR™ clinical trial at the BMT tandem meeting 6-2-2009
- Kiadis Pharma receives two orphan drug designations for Reviroc™ from the FDA 8-12-2008
- Kiadis Pharma announces positive clinical results for ATIR™ in mismatched bone marrow transplantations - Kiadis Pharma proceeds with pivotal trial ATIR™ 4-12-2008
- Kiadis Pharma announces continued collaboration with Professor Velardi on its lead product ATIR™ 28-11-2008
